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Name: Mitogen-activated protein kinase 1 - rat
Alternative names: Erk2, p42-MAPK, MAPK2
Taxonomy: [Rattus norvegicus] Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein Size: 358 aa
mRNA Size: 1467 bp
MW: 41276 Da
pI: 6.5
Activator MKKs: MAP2K1 (MEK1); MAP2K2 (MEK2)
Activation site: TEY (pThr-183 and pTyr-185)
Protein sequence [FASTA]:
>mkr|RAN000001|MK1_RAT|Mitogen-activated protein kinase 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Cross references
RefSeq: Protein: NP_446294.1.
Nucleotide sequence: NM_053842.1.
NCBI Gene: 116590 [MAPK1 mitogen-activated protein kinase 1]
UniProtKB: P63086 [MAPK1]
RCSB PDB: 1ERK
RCSB PDB: 1GOL
RCSB PDB: 2ERK
RCSB PDB: 2FYS
RCSB PDB: 2GPH
RCSB PDB: 2Z7L
RCSB PDB: 3C9W
RCSB PDB: 3ERK
RCSB PDB: 3O71
RCSB PDB: 3QYW
RCSB PDB: 3QYZ
RCSB PDB: 3R63
RCSB PDB: 4ERK