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Name: Mitogen-activated protein kinase 3 - human
Alternative names: Erk1, p44-MAPK, PRKM3
Taxonomy: [Homo sapiens] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo.
Protein Size: 379 aa
mRNA Size: 1902 bp
MW: 43136 Da
pI: 6.28
Activator MKKs: MAP2K1 (MEK1); MAP2K2 (MEK2)
Activation site: TEY (pThr-202 and pTyr-204)
Protein sequence [FASTA]:
>mkr|HOS000003|MK3_HUMAN|Mitogen-activated protein kinase 3 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL KELIFQETARFQPGVLEAP
Cross references
RefSeq: Protein: NP_001035145.1.
Nucleotide sequence: NM_001040056.1.
RefSeq: Protein: NP_001103361.1.
Nucleotide sequence: NM_001109891.1.
RefSeq: Protein: NP_002737.2.
Nucleotide sequence: NM_002746.2.
UniProtKB: P27361 [ MAPK3 ]
NextProt: NX_P27361
[ Mitogen-activated protein kinase 3 ]
HPRD: 03479
[ ERK1 ]
RCSB PDB: 2ZOQ